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Biliary complications (cholelithiasis, cholecystitis) represent a class effect attributable to reduced gallbladder motility, with incidence approximately 1.5-2.5-fold higher than placebo in long-term trials

Alternate injection locations to avoid irritation and discomfort in one spot- consider the abdomen, thigh, or upper arm as alternative sites

A 52 week study comparing the efficacy and safety of once weekly IcoSema and once weekly insulin icodec, both treatment arms with or without oral anti diabetic drugs, in participants with type 2 diabetes inadequately controlled with daily basal insulin (COMBINE 1)

AMPK activation promotes -oxidation and inhibits lipogenesis and triglyceride resynthesis (13, 26)

Human clinical applications remain unestablished