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Importantly, a phase I study showed that VLX1570 has antitumor effects in patients with multiple myeloma, although two patients developed severe pulmonary toxicity (Rowinsky et al., 2020)

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Deletion of the FOXF1 gene in mice, for example, was associated with spinal deformations and fusion of vertebrae [92], while deletions of PAX1 were associated with aberrant vertebrae formation during axial skeleton development due to the key role played by PAX1 in sclerotome formation [94]