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Stanford University shares in a multi-institutional agreement concerning intellectual property generated by this research

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The amount and type of GLP-1 produced depends on: The specific nutrients triggering L-cell receptors The health and density of L-cell populations The gut microbiomes capacity to produce short-chain fatty acids The presence of factors that enhance or inhibit L-cell function Key Insight: L-cells dont just respond to food quantitythey respond to specific nutrient signals

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[PubMed] Fling RR, Doskey CM, Fader KA, Nault R, Zacharewski TR (2020) 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) dysregulates hepatic one carbon metabolism during the progression of steatosis to steatohepatitis with fibrosis in mice