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Several pharmaceutical companies have explored transdermal delivery systems to avoid injections, but these formulations have not completed Phase III clinical trials or received FDA clearance

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A single-layered cheek pouch was prepared and continuously superfused with PSS warmed to 37C and equilibrated with a 0% O 2 -5% CO 2 -95% N 2 mixture to ensure that all O 2 delivery occurred via the microcirculation