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In some countries hydroxocobalamin has completely replaced cyanocobalamin as first choice for vitamin B 12 therapy because it is retained in the body longer and can be administered at intervals of up to three months

Likewise, a vitamin B-complex, which includes folate and other useful B-vitamins, may be more beneficial than B12 alone

Why does vitamin B12 cause nausea

A B12 injections effect can last anywhere from a couple of weeks to a few months, and the difference comes down to why you are deficient, how well your body holds on to B12, and the dose and schedule you are on