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Therefore, although there is no apparent evidence at the current time for overlapping mechanisms between the development of NAION and nAMD, it may be interesting to consider the involvement from impaired ocular blood flow (probably based on hypoperfusion of SPCAs) as a possible common mechanism of both conditions, and to investigate if GLP-1RAs or GIP/GLP-1RA (tirzepatide) can affect directly or indirectly the perfusion of SPCAs and choroidal capillaries