[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Martinez-Outschoorn UE, Sotgia F, Lisanti MP
Erythropoietic protoporphyria , caused by ferrochelatase deficiency producing phototoxic protoporphyrin IX accumulation in erythrocytes, plasma, and skin , provides a research model for studying MC1R-mediated photoprotection in a disease context where protection from visible light-induced phototoxicity is the primary biological endpoint
Transcriptomic profiling and quantification data of oocytes from young, aged, and uridine-treated aged mice are provided in Supplementary Data 1
Together, these findings reveal that ferroptosis suppression via NRF2 activation or ACSL4 inhibition underpins resistance to standard targeted therapies in ccRCC
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