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It is a synthetic hexapeptide patterned from the N-terminal end of the protein SNAP-25 (synaptosome-associated protein 25kDa), which is a component of the SNARE (soluble NSF attachment protein receptor) complex [23]

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Extracellular vesicles from endothelial progenitor cells reverse dexamethasone-induced GSH dyssynthesis and changes in several markers of oxidative damage, preventing glucocorticoid-induced osteoporosis in mice by inhibiting ferroptosis of osteoblasts

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Thus, the incubations with DTT and diamide indicate a dynamic range of about five which is in line with another study using the same probe in the yeast cytosol (Morgan et al , 2011)