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Researchers discerned no correlation between the incidence of muscle cramps and factors such as edema, ascites, diuretic use, alcohol consumption, but have identified the presence of liver cirrhosis, higher total serum bilirubin levels, and lower serum albumin levels as risk factors for development of muscle cramps (25, 28)
The titration protocol (16 weeks for both components) effectively manages tolerability despite dual mechanism activation (Enebo et al., 2021)
Additionally, Chinese herbal medicines play a vital role in restoring immune balance by modulating the function of immune cells, including T cells, macrophages, and dendritic cells (85, 86)
doi: 10.1093/ecco-jcc/jjw074 168 WangY.XieQ.ZhangY.MaW.NingK.XiangJ
Missing doses or stopping the medication regularly can also reduce effectiveness
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