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In vitro experiments confirmed that SPY1 overexpression significantly activated the GCH1/BH4 signaling pathway in NSC-34 cells transfected with the human SOD1 G93A gene

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Since different laboratories utilise a wide range of synthesis methods, including template-based calcination, hydrothermal and solvothermal reactions, resulting CQDs often display inconsistencies in size, charge, and fluorescence behaviour [167]

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