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Fluoride being beneficial at minimal concentrations was used for dental caries prevention, but excessive exposure of fluoride has been associated with numerous health disorders including skeletal and dental fluorosis, weakening of bones making them more prone to fractures, impaired intelligence, stunted growth, reduced birth and fertility rates, and disruption of thyroid function

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10.1016/j.canlet.2020.05.012 [DOI] [PMC free article] [PubMed] [Google Scholar] Hassan M

Furthermore, understanding how this metabolites physiology level changes in connection to other aspects of clinical normalcy may be interesting (196)