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However, significant physiological differences between species must be considered when interpreting veterinary data for human clinical applications

Figure: chemical structure of cagrilintide

As an independent pathological entity, hyperuricemia extends beyond gout pathogenesis to contribute to systemic comorbidities, including atherosclerosis, chronic kidney disease, and metabolic syndrome

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Thawing, seeding, culture, differentiation and maintenance of HepaRG cells for toxicity study were performed as described in the HepaRG TM Cell User Guide provided by the firm and as previously described in the literature 18