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Steady dose escalation to higher doses than for glycaemic control are indicated if: BMI is 30 kg/m 2 , or BMI 27 to 30 kg/m 2 , and for the range 2730 kg/m 2 if there is one weight-related comorbidity (hypertension, dyslipidaemia, cardiovascular disease, obstructive sleep apnoea, prediabetes or T2D

When combined with a wellness program, such as those from the Toronto Functional Medicine Centre, IV therapy may strengthen immunity and reduce fatigue, pain, and inflammation

Metformin IR is taken twice daily, while the extended-release formulation allows once-daily dosing

10.1016/j.apnr.2023.151745 79

Dheeraj Kapoor, head, endocrinology, Kokilaben Dhirubhai Ambani Hospital, Mumbai, adds, These drugs are not a quick-fix at a population level