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Any references to signaling pathways or molecular systems in scientific literature are included strictly for literature indexing and academic context

This is particularly evident in the treatment of brain diseases, where specialized delivery systems enable natural products to directly target the central nervous system via the nasal cavity, offering significant potential as a non-invasive treatment for such conditions

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For example, PREG is a lipophilic precursor of ALLO, which is also a metabolite of progesterone

The concentration changed, not the compound stability