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Similar content being viewed by others Introduction Cyclin D-dependent kinases 4 and 6 inhibitors (CDK4/6i) including palbociclib, ribociclib and abemaciclib in combination with endocrine therapy are the standard of care for patients with estrogen receptor-positive (ER + ) and human epidermal growth factor receptor 2-negative breast cancer 1,2,3,4,5