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GLP-1s diabetes benefits include substantial A1C reductions (typically 1-1.5% or more), low hypoglycemia risk due to glucose-dependent mechanism, weight loss rather than weight gain (unlike insulin and many other diabetes medications), cardiovascular protection demonstrated in outcome trials, and potential slowing of disease progression by preserving beta cell function

The appropriate rate of weight loss is a clinical determination, not an aesthetic one

Additionally, failing to rotate injection sites can cause lipodystrophy a condition where fatty tissue builds up in certain areas, creating hard lumps or dents that can interfere with medication absorption

Journal of Endocrinology 221.1 (2014): T1-T16