Natriuresis Acute infusion of GLP-1 has been shown to stimulate diuresis and natriuresis in both experimental (Skov et al., 2013
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Our current study is first to demonstrate that GLP-1-induced diuresis and natriuresis are attenuated in rats with HF induced by coronary artery ligation, in which the excessive activation of neural circuitry involving afferent and efferent renal nerves by GLP-1 might be implicated
5,6 In line with previous cardiovascular outcome studies, HARMONY Outcomes assessed as its primary outcome the three-point Major Adverse Cardiovascular Events (3-point MACE: cardiovascular death, non-fatal myocardial infarction and non-fatal stroke)
2a, b ) revealed recurrent hotspots around bonds 12, 14, 17, 19-21, 23-24, and 28-29, corresponding to the sequence FTSDVSSYEGQAAKEFIAWLVR