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Apelin inhibits diet-induced obesity by enhancing lymphatic and blood vessel integrity

Our study highlights several biological pathways by which GLP1 drugs may influence Alzheimers, including reducing inflammation, improving insulin signaling in the brain, and altering enzymes involved in the production of beta-amyloid. Diabetes is a well-known risk factor for dementia, in part because high blood sugar levels can damage blood vessels throughout the body, including in the brain

CJC-1295 activates adenylyl cyclase via GHRHR binding, increasing intracellular cAMP and triggering GH synthesis and secretion in pituitary somatotrophs

Gedebjerg, A., Johansen, C., Kragballe, K