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Caution is advised in patients with a history of pancreatitis, and monitoring for gallbladder disease is recommended

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potential differences in subgroup responses (e.g., with insulin resistance or obesity)

Another phase 2 RCT studying semglutide 2.4 mg vs placebo in patients with compensated NASH cirrhosis did not show any statistically significant difference in NASH resolution or improvement in liver fibrosis between the groups