Although paraquat may not be an efficient inhibitor of mitochondrial complex I, and so does not affect dopamine uptake [87,88], it does cause -synuclein aggregation in C57Bl/6 mice, and alters Parkin solubility, decreasing proteasome activity and causing cellular damage [87]
Similar benefits have also been demonstrated in patients with heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) [10, 11]
Consequently, GSTP inhibition effectively induces apoptosis, revealing its role as a key regulatory node in liver cancer (183)
You should also avoid overly sweet foods and drinks to better control any blood glucose spikes or dips
The "Slow and Steady" Titration The OASIS 4 and REDEFINE-1 trials emphasize that the best results come from long-term adherence, not rapid initial drops