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2010 Dec;11(12):1803-18

It works by mimicking the action of the naturally occurring hormone GLP-1, which regulates appetite and food intake through effects on the brain's satiety centres

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Your prescriber may recommend staying on a current dose longer if: You are experiencing ongoing nausea or vomiting You feel dizzy or fatigued You are losing weight steadily without needing an increase You prefer to remain on a well-tolerated dose Increasing too quickly can reduce adherence and make side effects harder to manage

Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction