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both exenatide and metformin had similar effects on microvascular endothelial function measured by the reactive hyperemic index (RHI), as well as levels of inflammatory and oxidative stress markers including C-reactive protein (CRP), oxidized LDL (oxLDL), and vascular cell adhesion molecule-1 (VCAM-1) levels [63]

If you cannot tolerate the side effects from recommended doses, sticking with the smaller dosage can be a solution, he says

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The gut converts the other 20% of T4-T3