3 For further description of the HDP subtypes, please see Table
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In all, persistent tissue injury provokes chronic inflammation and an increase of pro-fibrotic factors, such as TGF-1, ROS, PAI-1, ROCK, TNF, and TIMPs, which induce the phenotype transformation of precursor cells to myofibroblasts
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Further, through PI3KAKT signaling, GLP-1 suppresses Bax, enhances Bcl-2 expression, and inhibits Caspase-9/3 activation, preserving cell viability under degenerative stress offering an anti-apoptotic effect