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Kosiborod, M

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist licensed in the UK for the treatment of type 2 diabetes mellitus (as Mounjaro) and, more recently, for weight management (as Zepbound) in adults with obesity or overweight with weight-related comorbidities

After 4 weeks: If needed, increase your dose to 5 mg once a week

Hypoglycaemia (low blood sugar) may occur, particularly when Mounjaro is used in combination with other glucose-lowering agents such as insulin or sulphonylureas

The technical challenge is significant: GLP-1 receptor agonists are peptides that get destroyed in the stomach, so oral delivery requires specialized absorption-enhancing technology