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While several side effects are associated with isotretinoin treatment, recent research has demonstrated that the mental health problems and gastrointestinal diseases that were believed to be associated with the drug may not be caused by Accutane

Notably, our study of over 6000 Irish non-pregnant adults found that a deficient riboflavin status exacerbated the genetic risk of hypertension throughout adulthood, with a three-fold excess risk when the TT genotype occurred in combination with deficient riboflavin status compared to those without this polymorphism and normal riboflavin status (Reference Ward, Hughes and Strain111)