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This difficulty is primarily due to the complexities of diagnosis, which can be delayed or missed entirely, leading to underreporting of actual cases

5.4 Fibroblast activation and ECM remodeling Ferroptosisassociated inflammation activates myofibroblasts, which secrete matricellular proteins such as periostin and fibronectin

697,698 Viral hepatitis Clinical observations Viral hepatitis is a major risk factor for chronic liver disease and HCC, contributing to significant mortality worldwide, with hepatitis B and C accounting for the greatest global burden

The procedure takes 3045 minutes, depending on the target area

Soares, M