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We can make vitamin D with sunlight exposure to our skin, hence the nickname the sunshine vitamin

However, recent discoveries have expanded its relevance beyond metabolic health

Precautions According to the Institute of Medicine, no adverse effects are associated with vitamin B12 intake from food and supplements in healthy individuals

Most critically, patients with active malignancies or significant cancer risk factors may not be appropriate candidates due to the potential for promoting tumor growth and metastasis through angiogenesis stimulation

Evidence to date is primarily derived from preclinical and animal models, with emerging case series data