Biological Chemistry, 390(3), 191-214
useful proxy when clinical tools are unavailable Functional tests grip strength (dynamometer), sit-to-stand test, or consistent gym performance tracking Course Corrections If warning signs appear, the most impactful adjustments are: Increase protein intake to the higher end of the target range Prioritize leucine-rich sources (eggs, fish, poultry, dairy, and where supplementation is needed, high-quality EAA products) Confirm resistance training is consistent and progressive Two sessions per week minimum
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Oral supplements are more accessible to incorporate and more convenient than topical applications
The IC50 value of truncated Ex4 is 0.6 nM compared to 1.0 nM for Ex4 and 1.6 nM for GLP-1 (Runge et al., 2008)