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During this period, researchers continuously monitor key metabolic parameters to confirm that the model is returning to a baseline or stable state

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We collected a small cryo-EM dataset on this mutant in the presence of activating Ca 2+ , caffeine, and atorvastatin, which yielded both open ( ~ 3.4 ) and closed ( ~ 4.1 ) structures like wild-type RyR1 under the same experimental conditions (Fig

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