does semaglutide cross the blood brain barrier JCI Insight GLP-1 programs the neurovascular landscape:

192 Excessive glutamate in the synaptic cleft activates synaptic metabotropic glutamate receptors (mGluRs), which lead to neural excitotoxicity

Intranasal delivery of DSIP would allow targeted treatment in neurodegenerative diseases of the brain

This work was also supported by the Agence Nationale de la Recherche (ANR) with the MetaGenoPolis grant (ANR-11-DPBS-0001)

Neag E, Stupar Z, Varaticeanu C, Senila M, Roman C (2022) Optimization of lipid extraction from spirulina spp by ultrasound application and mechanical stirring using the Taguchi method of experimental design

Our findings indicate GH as a starvation signal that alerts the brain about energy deficiency, triggering key adaptive responses to conserve limited fuel stores