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For Type 1 diabetes, the evidence is still emerging
It is also noteworthy that MC1R activation might suppress the expression of COX-2 and cell adhesion molecules, suggesting a potential anti-inflammatory pathway through which MT-1 and similar compounds may exert further anti-fibrogenic action
Nevertheless, the MR-Egger intercept showed no evidence of directional pleiotropy and the MR estimates from additional sensitivity analyses were consistent with the null finding, meaning that considerable bias due to pleiotropy is unlikely
This data underscores the importance of establishing clear stopping criteria and safety thresholds
2015;309:R795-804
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