Fluid and electrolyte disturbances: Sodium retention Fluid retention Congestive heart failure in susceptible patients Potassium loss Hypokalemic alkalosis Hypertension Musculoskeletal: Muscle weakness Steroid myopathy Loss of muscle mass Osteoporosis Vertebral compression fractures Aseptic necrosis of femoral and humeral heads Pathologic fracture of long bones Gastrointestinal: Peptic ulcer with possible subsequent perforation and hemorrhage Pancreatitis Abdominal distention Ulcerative esophagitis Dermatological: Impaired wound healing Thin fragile skin Facial erythema Increased sweating May suppress reactions to skin tests Petechiae and ecchymoses Neurological: Convulsions Increased intracranial pressure with papilledema (pseudotumor cerebri) usually after treatment Vertigo Headache Ophthalmic: Posterior subcapsular cataracts Increased intraocular pressure Glaucoma Endocrine: Menstrual irregularities Development of cushingoid state Suppression of growth in children Secondary adrenocortical and pituitary unresponsiveness, particularly in times of stress, as in trauma, surgery, or illness Decreased carbohydrate tolerance Manifestations of latent diabetes mellitus Increased requirements for insulin or oral hypoglycemic agents in diabetics Metabolic: Negative nitrogen balance due to protein catabolism Miscellaneous: Hyperpigmentation or hypopigmentation Subcutaneous and cutaneous atrophy Sterile abscess Postinjection flare following intra-articular use Charcot-like arthropathy Itching, burning, tingling in the ano-genital region A
Regarding inflammatory signaling pathways in the cornea, TB-500 might mediate NFB inflammatory signaling pathways, which could have anti-inflammatory effects
Fact: Skin renewal takes 48 weeks
Weeks 1-2: The Quiet Start Most users report minimal changes during the first two weeks
Common guidelines include: Initial dose: Often 0.5 mg/kg/day for the first month Typical dose: 0.51.0 mg/kg/day based on response and tolerance Cumulative dose: 120150 mg/kg over a complete course Administration: Take with food to increase absorption For example, an 80 kg person may be prescribed 20 mg twice daily to approach a 1 mg/kg/day regimen over 45 months
