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MTHFR polymorphism and methylation MTHFR polymorphism is also associated with global methylation activity

Aug 19 2020;doi:10.1016/j.cgh.2020.08.040 Fritscher-Ravens A, Pflaum T, Mosinger M, et al

Animal doses cannot be directly extrapolated to humans Key Research Findings# Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice , published in Biochemical Pharmacology (Neelakantan H et al., 2018

This led researchers to wonder if GIP agonists would even work in the population that needed them most

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