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In a phase 2 trial (NCT02970942) of 320 individuals with biopsy-confirmed MASH, semaglutide treatment significantly increased the number of patients with resolution of MASH versus placebo 5

doi: 10.3389/fendo.2025.1711016 Received 23 September 2025 Revised 16 December 2025 Accepted 31 December 2025 Published 27 February 2026 Volume 16 - 2025 Edited by Antonio Simone Lagan, University of Palermo, Italy Reviewed by Hui Li, First Peoples Hospital of Changzhou, China Filipa Cristina Costa Ferreira, Instituto Nacional de Pesquisa Agropecuria e Veterinria (INIAV), Portugal Updates Copyright 2026 Xie, Zhang, Lin, Cheng and Huang