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Such off-label use, i.e., made in the absence of an FDA approval for this indication, in itself is reason for carefully conducted, evidence-based clinical trials, say the researchers, who reported results in JAMA Psychiatry

To help normalize this experience, review the data below highlighting estimated symptom prevalence during the initial titration phase, alongside their specific physiological triggers: The most reassuring takeaway from large-scale clinical trials is that these symptoms are transient

Nutrients 15, 811 (2023)

Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists

There were also concerns about rare cases of pancreatitis (still more frequent in patients with diabetes) and thyroid cancer (there is a black box warning)