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The strong synergy with PEA makes combination therapy particularly attractive for patients with inadequate response to standard treatments.[7][22] Advantages: Addresses nociplastic pain mechanisms via mGlu2 upregulation

Y., DePinho, R

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Excess accumulation of Cr negatively influences the activity of the cell cycle and causes an imbalance of elemental concentration, enzyme activity, and other metabolic processes, which leads to the induced generation of reactive oxygen species and oxidative stress in several plant species [36]

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