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Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)

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Considering the overlap in psychiatric symptoms between MDD and ME/CFS, it raises the possibility that probiotics could similarly benefit those with chronic fatigue [90]

Peptide research, especially involving blends and stacks, requires a methodical approach to ensure reliable and reproducible results