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Similarly, early tau aggregation in the trans-entorhinal region is associated with more severe apathy (Yasuno et al., 2020)

10.1089/clo.2006.0020 61 HuangJ.OkukaM.McLeanM.KeefeD

The dose can be gradually increased as the patients tolerance improves

Exercise is known to induce oxidative stress by increasing the generation of the reactive oxygen species (ROS), which is followed by lipid peroxidation and protein oxidation [59]