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Proteins on this pathway have targeted assays available via the CPTAC Assay Portal For a description of pathway objects, see the WikiPathways Legend

The Most Studied Pathways, being the most extensively researched and containing a larger number of identified pathway genes, along with Gene-Associated Pathways, which are closely related to AD pathology-associated genes and often focused on drug development, are both more likely to yield natural products with multiple gene targets

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The mitochondrial mechanism (a redox-cycling alternative electron carrier that feeds cytochrome c oxidase, raising ATP, cerebral oxygen use and blood flow, and crossing the blood-brain barrier easily)

In a recent review article, Hardingham and Do [17] presented evidence indicating that NMDAR hypofunction and oxidative stress may be reciprocally linked