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Key Points Topiramate (Topamax) is an anticonvulsant used to treat epilepsy and migraines Topamax is not FDA-approved for weight loss, but weight loss is a side effect Topiramate is part of Qsymia, a combination weight loss drug of phentermine and topiramate Studies show that topiramate results in a 5-7% weight loss over 6 months Topamax (topiramate) was designed to calm overactive electrical signals in the brain