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Adipocytes and bone marrow stromal cells in the TME can promote the resistance of tumor cells to ASNase treatment by supplying Gln and cysteine to leukemia cells, 348,349 and cancer-associated fibroblasts can secrete Asp to promote solid tumor growth

c-MYC induces ASS1 expression by directly binding its promoter and increasing the intracellular arginine capacity (Tsai et al., 2012)

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Ketogenesis occurs in the liver, specifically, in hepatocytes, through the mitochondrial -oxidation of fatty acids

Therefore, it is suggestive that there are definite benefits for overweight and obese individuals to increase their intake of leucine and/or total protein as a means for appetite and weight control