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While those studies measured endogenous GLP-1 in blood samples rather than pharmaceutical preparations, the principle holds: peptides and temperature are not friends

What the Clinical Trial Evidence Shows Phase 2 trial data show the 12 mg dose achieved approximately 17.5% body weight reduction at 24 weeks and 24.2% at 48 weeks

doi: 10.3390/microorganisms6030061, 28 DannenmannM.KlennerF.BnigkJ.PavlistaM.NapoleoniM.HillierJ.et al

The thermal reaction in your tissues stimulates your bodys natural healing response and causes new collagen to form and new elastin fibers to be produced

Approximately 10-15% of patients are "non-responders" who lose less than 5% of body weight despite adherence