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Mitochondrial DAMPs activate PRRs on glial cell surfaces, leading to the release of pro-inflammatory factors, activation of inflammatory pathways, and exacerbation of mitochondrial damagecreating a vicious cycle of mitochondrial dysfunction and neuroinflammation [276, 331]

The best time to raise this is before you start tirzepatide or adjust your dose, not after

For oral GLP-1s in particular, understanding both the pace of adoption and the profile of early adopters is essential to launch success, and to being first to insight

Limitations One limitation of this study is that it is a narrative rather than a systematic review

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