Le DSIP (Delta Sleep-Inducing Peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) is a nonapeptide isolated in 1977 by Schoenenberger from rabbit venous blood subjected to electrical stimulation of the thalamus
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It is approved for chronic weight management in adults and children 6 years and older with obesity due to specific genetic conditions, including proopiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1 (PCSK1), or leptin receptor (LEPR) deficiency, or Bardet-Biedl syndrome
In its initial announcements, CMS indicated that the GLP-1 Bridge program would run from July 1, 2026, through the end of the year, with the BALANCE Model beginning in January 2027
AMG-337 is a small molecule, ATP-competitive, highly selective inhibitor of the c-MET receptor