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It is important to note that randomized trials typically involve a highly selective group of individuals who do not accurately reflect the general population with T2DM

Some researchers tolerate dose increases faster

Ferrannini, G

A nivel de tejido adiposo, la contribucin del agonismo GIP y GLP-1 reduce la infiltracin de macrfagos M1 y de citoquinas proinflamatorias como leptina, aumenta la adiponectina e incrementa la insulinosensibilidad, mejorando la disfuncin adipocitaria39