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Samples were prepared via several different methodologies to obtain the most reproducible output and ensure that no major experimental artefacts were introduced during the sample processing

By contrast lets revisit the elephants butt and insert the lollipop in the muscle

(ref) Hsieh MJ, Liu HT, Wang CN, Huang HY, Lin Y, Ko YS, Wang JS, Chang VH, Pang JS

Degradation versus Inhibition: development of proteolysis-targeting chimeras for overcoming statin-induced compensatory upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase