Free Radic Biol Med 112:616630
The most common symptoms, which are mild and temporary, include abdominal pain, loose stools, and increased flatulence (mostly associated with oral supplementation)
Under ER stress, the integrated stress response (ISR) pathway is activated, leading to the phosphorylation of eIF2 and subsequent upregulation of ATF4, a transcription factor that increases CHAC1 expression
Adding less water than the label calls for is the opposite and more dangerous problem it over-concentrates the solution and can cause an inadvertent overdose
Almost all antioxidant genes involved in ferroptosis, such as NADPH regeneration, glutathione-regulated and lipid peroxidation, may be potential therapeutic targets