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When combined with tesofensine's reuptake inhibition, the result is excessive sympathetic nervous system activation

Nausea, vomiting, and constipation are most common during initial weeks and dose increases, typically improving within days to weeks as the body adapts

The release of damage-associated molecular patterns by tumor cells undergoing ferroptosis also mediates antitumor immunity, and immune therapy can synergize with targeted therapy or radiotherapy through ferroptosis (153, 154)

Dysfunctional endothelial cells are less effective at producing anticoagulant substances like nitric oxide and prostacyclin, increasing thrombosis risk