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The clinical relevance of this axis is further supported by epidemiological evidence: a prospective cohort study demonstrated that teat skin condition was directly associated with clinical mastitis occurrence, with combined dry skin and skin lesions conferring nearly five-fold higher odds of clinical mastitis compared with normal teat skin 188 , underscoring teat skin integrity as a critical determinant of mammary health along this axis

Increased intracellular NAD was reported in selected cultured-cell experiments

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