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Most people are not deficient in vitamin B12, as it is abundant in many foods

While complications are rare, individuals with very sensitive skin, a history of keloid scarring, or certain skin conditions may face a higher risk for adverse effects

Specifically, dopaminergic neurons have a significant impact on brain regions involved in the rewarding and reinforcing effects of alcohol and other drugs, with the nucleus accumbens (NAc) being particularly prominent

More about compounding concerns An open letter from Eli Lilly and Company regarding certain practices related to Mounjaro and Zepbound (June 2024) FDA warns about adverse events from compounded semaglutide (May 2023) Novo Nordisk escalates legal actions to safeguard patients from potentially harmful compounded semaglutide drugs (May 2024) The Center for Medicine in the Public Interest's September 2025 handout explains concerns about mass compounding

Mauro (who co-reviewed with M